{"id":539,"date":"2022-10-05T12:39:45","date_gmt":"2022-10-05T12:39:45","guid":{"rendered":"https:\/\/antyrad.pl\/sklep\/idra-21-purity-%e2%89%a5-99-1000mg\/"},"modified":"2022-10-05T12:39:45","modified_gmt":"2022-10-05T12:39:45","slug":"idra-21-2","status":"publish","type":"product","link":"https:\/\/antyrad.pl\/en\/sklep\/idra-21-2\/","title":{"rendered":"IDRA-21, purity \u2265 99% 1000mg"},"content":{"rendered":"<h1>IDRA-21<\/h1>\n<ul>\n<li>\n<h2>Purity of IDRA-21\u2265 99%<\/h2>\n<\/li>\n<li>\n<h2>Net weight: 1000mg<\/h2>\n<\/li>\n<li>\n<h2>Cas No. : 22503-72-6<\/h2>\n<\/li>\n<li>\n<h2>Molecular Formula: <span title=\"Carbon\">C8H9ClN2O2S<\/span><\/h2>\n<\/li>\n<li>\n<h2>Molar mass: 232.68 g-mol-1<\/h2>\n<\/li>\n<li>\n<h2>Application: product for laboratory testing.<\/h2>\n<\/li>\n<\/ul>\n<h3>The IDRA-21 molecule is an allosteric modulator of the AMPA receptor and a benzothiadiazine derivative. It is a chiral molecule in which the active form is (+)-IDRA-21.<\/h3>\n<h4>IDRA-21 has demonstrated its nootropic properties in animal model studies. It has significantly improved learning ability and memory. Irda-21 is 20 to 30 times more effective compared to <a href=\"https:\/\/antyrad.pl\/sklep\/aniracetam\/\">aniracetam<\/a>. It specifically helps reverse cognitive deficits caused by alprazolam (Xanax) or the amnesic effects of scopolamine. It produces long-lasting effects lasting up to 48 hours after assimilating a single dose of the pryparat. The molecule&#8217;s mechanism of action is not fully explained. It is concluded that the mechanism of interaction mainly involves the promotion and induction of long-term potentiation between synapses.<\/h4>\n<h4>IDRA-21 may not cause neurotoxicity under normal conditions. Potentially high doses of pryparat may have neurotoxic effects. This agent should not be sotos in post-stroke patients.<\/h4>\n<h4>Compared to other ampakines or benzoylpiperidine-derived AMPA receptor enhancers, the IDRA-21 agent was more potent than CX-516, but weaker than CX-546. To date, newer benzothiadiazide derivatives have been developed. They feature enhanced action potential compared to IDRA-21. These measures have not been clinically tested. Studies on IDRA-21 have been discontinued in favor of benzoylpiperidine and benzoylpyrrolidine CX series drugs due to their potential neurotoxicity at high doses.<\/h4>\n<h4>Attention! The offered IDRA-21 is a substance of bardoz high purity. It is used only for lab tests and must not be consumed in any form. The offered product is sold as a chemical reagent.<\/h4>\n<h3><\/h3>\n<h3>Scientific reference from Wikipedia:<\/h3>\n<ol>\n<li>\n<h5>Arai AC, Xia YF, Kessler M, Phillips D, Chamberlin R, Granger R, Lynch G (September 2002). &#8220;Effects of 5&#8242;-alkyl-benzothiadiazides on (R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor biophysics and synaptic responses&#8221;. Molecular Pharmacology. 62 (3): 566-77. doi:10.1124\/mol.62.3.566. PMID 12181433.<\/h5>\n<\/li>\n<li>\n<h5>Black MD (April 2005). &#8220;Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data&#8221;. Psychopharmacology. 179 (1): 154-63. doi:10.1007\/s00213-004-2065-6. PMID 15672275. S2CID 5869366.<\/h5>\n<\/li>\n<li>\n<h5>Phillips D, Sonnenberg J, Arai AC, Vaswani R, Krutzik PO, Kleisli T, et al. (May 2002). &#8220;5&#8242;-alkyl-benzothiadiazides: a new subgroup of AMPA receptor modulators with improved affinity&#8221;. Bioorganic &amp; Medicinal Chemistry. 10 (5): 1229-48. CiteSeerX 10.1.1.113.7845. doi:10.1016\/S0968-0896(01)00405-9. PMID 11886787.<\/h5>\n<\/li>\n<li>\n<h5>Nagarajan N, Quast C, Boxall AR, Shahid M, Rosenmund C (November 2001). &#8220;Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546&#8221;. Neuropharmacology. 41 (6): 650-63. doi:10.1016\/S0028-3908(01)00133-2. PMID 11640919. S2CID 7796112.<\/h5>\n<\/li>\n<li>\n<h5>Buccafusco JJ, Weiser T, Winter K, Klinder K, Terry AV (January 2004). &#8220;The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys.&#8221; Neuropharmacology. 46 (1): 10-22. doi:10.1016\/j.neuropharm.2003.07.002. PMID 14654093. S2CID 26443642.<\/h5>\n<\/li>\n<li>\n<h5>Thompson DM, Guidotti A, DiBella M, Costa E (August 1995). &#8220;7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys&#8221;. Proceedings of the National Academy of Sciences of the United States of America. 92 (17): 7667-71. bibcode:1995PNAS&#8230;92.7667T. doi:10.1073\/pnas.92.17.7667. PMC 41206. PMID 7644474.<\/h5>\n<\/li>\n<li>\n<h5>Uzunov DP, Zivkovich I, Pirkle WH, Costa E, Guidotti A (August 1995). &#8220;Enantiomeric resolution with a new chiral stationary phase of 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide, a cognition-enhancing benzothiadiazine derivative&#8221;. Journal of Pharmaceutical Sciences. 84 (8): 937-42. doi:10.1002\/jps.2600840807. PMID 7500277<\/h5>\n<\/li>\n<\/ol>\n<h5><\/h5>\n","protected":false},"excerpt":{"rendered":"<p>IDRA-21 is 20 to 30 times more potent than Aniracetam. The issue supports cognitive processes also has its dark side&#8230;. in high doses IDRA-21 can exhibit neurotoxic effects!<\/p>\n","protected":false},"featured_media":496,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_cat":[164],"product_tag":[204,198,206,207,201,202],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>IDRA-21, purity \u2265 99% 1000mg - NONSENSIA, Laboratorium.<\/title>\n<meta name=\"description\" content=\"IDRA-21 is 20 to 30 times more potent than Aniracetam. The release supports cognitive processes. 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